Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

Alzheimer's disease is linked to metabolic syndrome and Type-2 diabetes, but the mechanism behind this association is unclear. Here, the authors show that elevated glucose and amyloid ß work together to increase nitrosative stress, leading to aberrant mitochondrial activity and synaptic dysfunc...

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Bibliographic Details
Main Authors: Mohd Waseem Akhtar, Sara Sanz-Blasco, Nima Dolatabadi, James Parker, Kevin Chon, Michelle S. Lee, Walid Soussou, Scott R. McKercher, Rajesh Ambasudhan, Tomohiro Nakamura, Stuart A. Lipton
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10242

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https://doi.org/10.1038/ncomms10242

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