Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
Alzheimer's disease is linked to metabolic syndrome and Type-2 diabetes, but the mechanism behind this association is unclear. Here, the authors show that elevated glucose and amyloid ß work together to increase nitrosative stress, leading to aberrant mitochondrial activity and synaptic dysfunc...
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Bibliographic Details
Main Authors: |
Mohd Waseem Akhtar,
Sara Sanz-Blasco,
Nima Dolatabadi,
James Parker,
Kevin Chon,
Michelle S. Lee,
Walid Soussou,
Scott R. McKercher,
Rajesh Ambasudhan,
Tomohiro Nakamura,
Stuart A. Lipton |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2016-01-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms10242
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