Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
Alzheimer's disease is linked to metabolic syndrome and Type-2 diabetes, but the mechanism behind this association is unclear. Here, the authors show that elevated glucose and amyloid ß work together to increase nitrosative stress, leading to aberrant mitochondrial activity and synaptic dysfunc...
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Nature Publishing Group
2016-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10242 |
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doaj-9fb0c0af61564f9ba2f975e9d457f2352021-05-11T11:05:03ZengNature Publishing GroupNature Communications2041-17232016-01-017111110.1038/ncomms10242Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylationMohd Waseem Akhtar0Sara Sanz-Blasco1Nima Dolatabadi2James Parker3Kevin Chon4Michelle S. Lee5Walid Soussou6Scott R. McKercher7Rajesh Ambasudhan8Tomohiro Nakamura9Stuart A. Lipton10Center for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery InstituteCenter for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery InstituteCenter for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery InstituteCenter for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery InstituteCenter for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery InstituteCenter for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery InstituteCenter for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery InstituteCenter for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery InstituteCenter for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery InstituteCenter for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery InstituteCenter for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery InstituteAlzheimer's disease is linked to metabolic syndrome and Type-2 diabetes, but the mechanism behind this association is unclear. Here, the authors show that elevated glucose and amyloid ß work together to increase nitrosative stress, leading to aberrant mitochondrial activity and synaptic dysfunction.https://doi.org/10.1038/ncomms10242 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Mohd Waseem Akhtar Sara Sanz-Blasco Nima Dolatabadi James Parker Kevin Chon Michelle S. Lee Walid Soussou Scott R. McKercher Rajesh Ambasudhan Tomohiro Nakamura Stuart A. Lipton |
| spellingShingle |
Mohd Waseem Akhtar Sara Sanz-Blasco Nima Dolatabadi James Parker Kevin Chon Michelle S. Lee Walid Soussou Scott R. McKercher Rajesh Ambasudhan Tomohiro Nakamura Stuart A. Lipton Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation Nature Communications |
| author_facet |
Mohd Waseem Akhtar Sara Sanz-Blasco Nima Dolatabadi James Parker Kevin Chon Michelle S. Lee Walid Soussou Scott R. McKercher Rajesh Ambasudhan Tomohiro Nakamura Stuart A. Lipton |
| author_sort |
Mohd Waseem Akhtar |
| title |
Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation |
| title_short |
Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation |
| title_full |
Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation |
| title_fullStr |
Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation |
| title_full_unstemmed |
Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation |
| title_sort |
elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein s-nitrosylation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-01-01 |
| description |
Alzheimer's disease is linked to metabolic syndrome and Type-2 diabetes, but the mechanism behind this association is unclear. Here, the authors show that elevated glucose and amyloid ß work together to increase nitrosative stress, leading to aberrant mitochondrial activity and synaptic dysfunction. |
| url |
https://doi.org/10.1038/ncomms10242 |
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