Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
Alzheimer's disease is linked to metabolic syndrome and Type-2 diabetes, but the mechanism behind this association is unclear. Here, the authors show that elevated glucose and amyloid ß work together to increase nitrosative stress, leading to aberrant mitochondrial activity and synaptic dysfunc...
Main Authors: | Mohd Waseem Akhtar, Sara Sanz-Blasco, Nima Dolatabadi, James Parker, Kevin Chon, Michelle S. Lee, Walid Soussou, Scott R. McKercher, Rajesh Ambasudhan, Tomohiro Nakamura, Stuart A. Lipton |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms10242 |
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