Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD

Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD

Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are increasing in prevalence but lack targeted therapeutics. Although the pathological mechanisms behind these diseases remain unclear, both ALS and FTD are characterized pathologically by aberr...

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Bibliographic Details
Main Authors: Thomas J. Hedl, Rebecca San Gil, Flora Cheng, Stephanie L. Rayner, Jennilee M. Davidson, Alana De Luca, Maria D. Villalva, Heath Ecroyd, Adam K. Walker, Albert Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neuroscience
Subjects:
amyotrophic lateral sclerosis
frontotemporal dementia
proteomics
mass spectrometry
protein aggregation
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00548/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00548/full

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