p53-dependent activation of microRNA-34a in response to etoposide-induced DNA damage in osteosarcoma cell lines not impaired by dominant negative p53 expression.

p53-dependent activation of microRNA-34a in response to etoposide-induced DNA damage in osteosarcoma cell lines not impaired by dominant negative p53 expression.

Osteosarcoma (OS) is the most common primary malignant bone tumor and prevalently occurs in the second decade of life. Etoposide, a chemotherapeutic agent used in combined treatments of recurrent human OS, belongs to the topoisomerase inhibitor family and causes DNA breakage. In this study we evalua...

Full description

Bibliographic Details
Main Authors: Chiara Novello, Laura Pazzaglia, Amalia Conti, Irene Quattrini, Serena Pollino, Paola Perego, Piero Picci, Maria Serena Benassi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4260944?pdf=render

Internet

http://europepmc.org/articles/PMC4260944?pdf=render

Similar Items