5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts.

5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts.

The lipoxygenase isoform of 5-lipoxygenase (5-LOX) is reported to be overexpressed in human rheumatoid arthritis synovial tissue and involved in the progress of inflammatory arthritis. However, the detailed mechanism of how 5-lipoxygenase regulates the inflammatory response in arthritis synovial tis...

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Bibliographic Details
Main Authors: Han-Ching Lin, Tzu-Hung Lin, Ming-Yueh Wu, Yung-Cheng Chiu, Chih-Hsin Tang, Mann-Jen Hour, Houng-Chi Liou, Huang-Ju Tu, Rong-Sen Yang, Wen-Mei Fu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4168259?pdf=render

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http://europepmc.org/articles/PMC4168259?pdf=render

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