HIV delays IFN-α production from human plasmacytoid dendritic cells and is associated with SYK phosphorylation.

HIV delays IFN-α production from human plasmacytoid dendritic cells and is associated with SYK phosphorylation.

Plasmacytoid dendritic cells (pDC) are the major producers of type I interferons (IFNs) in humans and rapidly produce IFN-α in response to virus exposure. Although HIV infection is associated with pDC activation, it is unclear why the innate immune response is unable to effectively control viral rep...

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Bibliographic Details
Main Authors: Calvin C Lo, Jordan A Schwartz, Dylan J Johnson, Monica Yu, Nasra Aidarus, Shariq Mujib, Erika Benko, Martin Hyrcza, Colin Kovacs, Mario A Ostrowski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3365039?pdf=render

Internet

http://europepmc.org/articles/PMC3365039?pdf=render

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