Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity

Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity

Group 2 innate lymphoid cells (ILC2s) are tissue resident in the lung and activated by inhaled allergens via epithelial-derived alarmins including IL-33. Activated ILC2s proliferate, produce IL-5 and IL-13, and induce eosinophilic inflammation. Here, we report that intranasal IL-33 or the protease a...

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Bibliographic Details
Main Authors: Laura Mathä, Mónica Romera-Hernández, Catherine A. Steer, Yi Han Yin, Mona Orangi, Hanjoo Shim, ChihKai Chang, Fabio M. Rossi, Fumio Takei
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
group 2 innate lymphoid cells
allergic lung inflammation
tissue resident
migration
liver inflammation
parabiosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.679509/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.679509/full

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