Lack of α2C-Adrenoceptor Results in Contrasting Phenotypes of Long Bones and Vertebra and Prevents the Thyrotoxicosis-Induced Osteopenia.

A series of studies have demonstrated that activation of the sympathetic nervous system (SNS) causes osteopenia via β2-adrenoceptor (β2-AR) signaling. However, in a recent study, we found an unexpected and generalized phenotype of high bone mass in female mice with chronic sympathetic hyperactivity,...

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Main Authors: Marilia Bianca Cruz Grecco Teixeira, Gisele Miyamura Martins, Manuela Miranda-Rodrigues, Iasmin Ferreira De Araújo, Ricardo Oliveira, Patrícia Chakur Brum, Cecilia Helena Azevedo Gouveia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4729682?pdf=render