A systems-level model reveals that 1,2-Propanediol utilization microcompartments enhance pathway flux through intermediate sequestration.

The spatial organization of metabolism is common to all domains of life. Enteric and other bacteria use subcellular organelles known as bacterial microcompartments to spatially organize the metabolism of pathogenicity-relevant carbon sources, such as 1,2-propanediol. The organelles are thought to se...

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Bibliographic Details
Main Authors: Christopher M Jakobson, Danielle Tullman-Ercek, Marilyn F Slininger, Niall M Mangan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-05-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5438192?pdf=render