Farnesoid X Receptor Activation Enhances Transforming Growth Factor β-Induced Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells

Farnesoid X Receptor Activation Enhances Transforming Growth Factor β-Induced Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells

Farnesoid X receptor (FXR) is a receptor for bile acids and plays an important role in the regulation of bile acid metabolism in the liver. Although FXR has been shown to affect hepatocarcinogenesis through both direct and indirect mechanisms, potential roles of FXR in epithelial–mesenchym...

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Bibliographic Details
Main Authors: Masahiko Kainuma, Ichiro Takada, Makoto Makishima, Keiji Sano
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
farnesoid X receptor
bile acid
hepatocellular carcinoma
epithelial–mesenchymal transition
guggulsterone
transforming growth factor β
N-cadherin
focal adhesion kinase
Online Access:http://www.mdpi.com/1422-0067/19/7/1898

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http://www.mdpi.com/1422-0067/19/7/1898

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