Mesencephalic Electrical Stimulation Reduces Neuroinflammation after Photothrombotic Stroke in Rats by Targeting the Cholinergic Anti-Inflammatory Pathway

Mesencephalic Electrical Stimulation Reduces Neuroinflammation after Photothrombotic Stroke in Rats by Targeting the Cholinergic Anti-Inflammatory Pathway

Inflammation is crucial in the pathophysiology of stroke and thus a promising therapeutic target. High-frequency stimulation (HFS) of the mesencephalic locomotor region (MLR) reduces perilesional inflammation after photothrombotic stroke (PTS). However, the underlying mechanism is not completely und...

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Bibliographic Details
Main Authors: Michael K. Schuhmann, Lena Papp, Guido Stoll, Robert Blum, Jens Volkmann, Felix Fluri
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
photothrombotic stroke
deep brain stimulation
mesencephalic locomotor region
neuroinflammation
choline acetyltransferase
alpha-7 nicotinic acetylcholine receptor
Online Access:https://www.mdpi.com/1422-0067/22/3/1254

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https://www.mdpi.com/1422-0067/22/3/1254

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