Case Report: Low Hematocrit Leading to Tacrolimus Toxicity
Tacrolimus is a calcineurin inhibitor characterized by a narrow therapeutic index and high intra- and inter-individual pharmacokinetic variability. Therapeutic drug monitoring in whole-blood is the standard monitoring procedure. However, tacrolimus extensively binds to erythrocytes, and tacrolimus w...
Main Authors: | Alexandre Piletta-Zanin, Aurélie De Mul, Nathalie Rock, Pierre Lescuyer, Caroline F. Samer, Frédérique Rodieux |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-08-01
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Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.717148/full |
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