Membrane transporter dimerization driven by differential lipid solvation energetics of dissociated and associated states

Membrane transporter dimerization driven by differential lipid solvation energetics of dissociated and associated states

Over two-thirds of integral membrane proteins of known structure assemble into oligomers. Yet, the forces that drive the association of these proteins remain to be delineated, as the lipid bilayer is a solvent environment that is both structurally and chemically complex. In this study, we reveal how...

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Bibliographic Details
Main Authors: Rahul Chadda, Nathan Bernhardt, Elizabeth G Kelley, Susana CM Teixeira, Kacie Griffith, Alejandro Gil-Ley, Tuğba N Öztürk, Lauren E Hughes, Ana Forsythe, Venkatramanan Krishnamani, José D Faraldo-Gómez, Janice L Robertson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
membrane transporter
dimerization
lipids
energetics
computational modeling
single-molecule
Online Access:https://elifesciences.org/articles/63288

Internet

https://elifesciences.org/articles/63288

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