A critical role of epigenetic inactivation of miR-9 in EVI1high pediatric AML

A critical role of epigenetic inactivation of miR-9 in EVI1high pediatric AML

Abstract Ectopic Viral Integration site 1 (EVI1) upregulation is implicated in 10–25% of pediatric acute myeloid leukemia (AML) and has an inferior outcome with current chemotherapy regimens. Here we report that EVI1 upregulation is associated with methylation of the miR-9 promoter and correlated wi...

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Bibliographic Details
Main Authors: Nupur Mittal, Liping Li, Yue Sheng, Chao Hu, Fuxing Li, Tongyu Zhu, Xiaohong Qiao, Zhijian Qian
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Molecular Cancer
Subjects:
EVI1
miR9
Hyper methylation
Pediatric acute myeloid leukemia (AML)
Hypomethylating agents
Online Access:http://link.springer.com/article/10.1186/s12943-019-0952-z

Internet

http://link.springer.com/article/10.1186/s12943-019-0952-z

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