EGFR copy number alterations in primary tumors, metastatic lymph nodes, and recurrent and multiple primary tumors in oral cavity squamous cell carcinoma

EGFR copy number alterations in primary tumors, metastatic lymph nodes, and recurrent and multiple primary tumors in oral cavity squamous cell carcinoma

Abstract Background The EGFR and downstream signaling pathways play an important role in tumorigenesis in oral squamous cell carcinoma (OSCC). Gene copy number alteration is one mechanism for overexpressing the EGFR protein and was also demonstrated to be related to lymph node metastasis, tumor inva...

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Bibliographic Details
Main Authors: Shiang-Fu Huang, Huei-Tzu Chien, Sou-De Cheng, Wen-Yu Chuang, Chun-Ta Liao, Hung-Ming Wang
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Cancer
Subjects:
Epidermal growth factor receptor (EGFR)
Gene amplification
Recurrence, metastasis
Multiple primary tumors, fluorescence in situ hybridization
Oral cavity squamous cell carcinoma
Online Access:http://link.springer.com/article/10.1186/s12885-017-3586-9

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http://link.springer.com/article/10.1186/s12885-017-3586-9

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