Mitochondriotropic and Cardioprotective Effects of Triphenylphosphonium-Conjugated Derivatives of the Diterpenoid Isosteviol

Mitochondriotropic and Cardioprotective Effects of Triphenylphosphonium-Conjugated Derivatives of the Diterpenoid Isosteviol

Mitochondria play a crucial role in the cell fate; in particular, reducing the accumulation of calcium in the mitochondrial matrix offers cardioprotection. This affect is achieved by a mild depolarization of the mitochondrial membrane potential, which prevents the assembly and opening of the mitocho...

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Bibliographic Details
Main Authors: Lara Testai, Irina Strobykina, Victor V. Semenov, Marina Semenova, Eleonora Da Pozzo, Alma Martelli, Valentina Citi, Claudia Martini, Maria C. Breschi, Vladimir E. Kataev, Vincenzo Calderone
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondria
Stevia rebaudiana Bertoni
tetraphenylphosphonium
isosteviol
cardioprotection
Online Access:https://www.mdpi.com/1422-0067/18/10/2060

Internet

https://www.mdpi.com/1422-0067/18/10/2060

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