Yaws re-emergence and bacterial drug resistance selection after mass administration of azithromycin: a genomic epidemiology investigation

Summary: Background: In a longitudinal study assessing the WHO strategy for yaws eradication using mass azithromycin treatment, we observed resurgence of yaws cases with dominance of a single JG8 sequence type and emergence of azithromycin-resistant Treponema pallidum subspecies pertenue (T p perte...

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Main Authors: Mathew A Beale, PhD, Marc Noguera-Julian, PhD, Charmie Godornes, BSc, Maria Casadellà, PhD, Camila González-Beiras, PhD, Mariona Parera, BSc, August Kapa Jnr, BSc, Wendy Houinei, MPH, James Wangi, MPH, Marc Corbacho-Monne, MBBS, Roger Paredes, PhD, Fernando Gonzalez-Candelas, ProfPhD, Michael Marks, PhD, Sheila A Lukehart, ProfPhD, Nicholas R Thomson, ProfPhD, Oriol Mitjà, PhD
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:The Lancet Microbe
Online Access:http://www.sciencedirect.com/science/article/pii/S2666524720301130