Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3

Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3

Signal transducer and activator of transcription 3 (STAT3) is an attractive therapeutic target for cancer treatment. In this study, we identify lycorine is an effective inhibitor of STAT3, leading to repression of multiple oncogenic processes in colon carcinoma. Lycorine selectively inactivates phos...

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Bibliographic Details
Main Authors: Song Wu, Yuling Qiu, Yingying Shao, Shuangshuang Yin, Rui Wang, Xu Pang, Junhong Ma, Chunze Zhang, Bo Wu, Sangho Koo, Lifeng Han, Yi Zhang, Xiumei Gao, Tao Wang, Haiyang Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
lycorine
STAT3
target
apoptosis
colorectal cancers
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00881/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00881/full

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