Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation

Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation

Abstract Background CIMP (CpG island methylator phenotype) is an epigenetic molecular subtype, observed in multiple malignancies and associated with the epigenetic silencing of tumor suppressors. Currently, for most cancers including gastric cancer (GC), mechanisms underlying CIMP remain poorly unde...

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Bibliographic Details
Main Authors: Nisha Padmanabhan, Huang Kie Kyon, Arnoud Boot, Kevin Lim, Supriya Srivastava, Shuwen Chen, Zhiyuan Wu, Hyung-O K Lee, Vineeth T. Mukundan, Charlene Chan, Yarn Kit Chan, Ong Xuewen, Jason J. Pitt, Zul Fazreen Adam Isa, Manjie Xing, Ming Hui Lee, Angie Lay Keng Tan, Shamaine Ho Wei Ting, Micah A. Luftig, Dennis Kappei, Warren D. Kruger, Jinsong Bian, Ying Swan Ho, Ming Teh, Steve George Rozen, Patrick Tan
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Genome Biology
Subjects:
Gastric cancer
CBS
CIMP
Inflammation
Online Access:https://doi.org/10.1186/s13059-021-02375-2

Internet

https://doi.org/10.1186/s13059-021-02375-2

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