JAK-STAT1/3-induced expression of signal sequence-encoding proopiomelanocortin mRNA in lymphocytes reduces inflammatory pain in rats

JAK-STAT1/3-induced expression of signal sequence-encoding proopiomelanocortin mRNA in lymphocytes reduces inflammatory pain in rats

<p>Abstract</p> <p>Background</p> <p>Proopiomelanocortin (POMC)-derived beta-endorphin<sub>1-31</sub> from immune cells can inhibit inflammatory pain. Here we investigated cytokine signaling pathways regulating POMC gene expression and beta-endorphin product...

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Bibliographic Details
Main Authors: Busch-Dienstfertig Melanie, Labuz Dominika, Wolfram Theresa, Vogel Nicole N, Stein Christoph
Format: Article
Language:English
Published: SAGE Publishing 2012-11-01
Series:Molecular Pain
Subjects:
Pain
Inflammation
Opioid peptides
Immune cells
Neuro-immune interactions
Cytokine signaling.
Online Access:http://www.molecularpain.com/content/8/1/83

Internet

http://www.molecularpain.com/content/8/1/83

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