Transplantation of Human Neural Stem Cells in a Parkinsonian Model Exerts Neuroprotection via Regulation of the Host Microenvironment

Transplantation of Human Neural Stem Cells in a Parkinsonian Model Exerts Neuroprotection via Regulation of the Host Microenvironment

Parkinson’s disease (PD) is characterized by a progressive loss of dopaminergic neurons and consequent dopamine (DA) deficit, and current treatment still remains a challenge. Although neural stem cells (NSCs) have been evaluated as appealing graft sources, mechanisms underlying the beneficial phenom...

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Bibliographic Details
Main Authors: Fu-Xing Zuo, Xin-Jie Bao, Xi-Cai Sun, Jun Wu, Qing-Ran Bai, Guo Chen, Xue-Yuan Li, Qiang-Yi Zhou, Yuan-Fan Yang, Qin Shen, Ren-Zhi Wang
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s disease
neural stem cells
transplantation
niche
endogenous de-differentiated astrocytes
Online Access:http://www.mdpi.com/1422-0067/16/11/25966

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http://www.mdpi.com/1422-0067/16/11/25966

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