Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative

• Main Authors: Dobričić Vladimir, Vladimirov Sote, Čudina Olivera
• Format: Article
• Language: English
• Published: University of Kragujevac, Faculty of Science 2016-01-01
• Series: Kragujevac Journal of Science
• Subjects: cortienic acid; amide; lipophilicity; RP-TLC
• Online Access: http://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2016/1450-96361638107D.pdf

Cortienic acid was obtained by periodic acid oxidation of fluocinolone acetonide, whereas corresponding amide was synthesized from the cortienic acid and ethyl ester of b-alanine by dicyclohexylcarbodiimide - hydroxybenzotriazole coupling procedure. Lipophilicity of the amide was evaluated by using reversed-phase thin-layer chromatography systems, consisting of ethanol and water in various ratios, and was higher in comparison to fluocinolone acetonide and cortienic acid.