Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative
Cortienic acid was obtained by periodic acid oxidation of fluocinolone acetonide, whereas corresponding amide was synthesized from the cortienic acid and ethyl ester of b-alanine by dicyclohexylcarbodiimide - hydroxybenzotriazole coupling procedure. Lipophilicity of the amide was evaluated by using...
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University of Kragujevac, Faculty of Science
2016-01-01
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doaj-9ff5979d14294888bb841cce626a2f492020-11-24T23:43:58ZengUniversity of Kragujevac, Faculty of ScienceKragujevac Journal of Science1450-96362466-55092016-01-0120163810711410.5937/KgJSci1638107D1450-96361638107DSynthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivativeDobričić Vladimir0Vladimirov Sote1Čudina Olivera2University of Belgrade, Faculty of Pharmacy, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Belgrade, SerbiaCortienic acid was obtained by periodic acid oxidation of fluocinolone acetonide, whereas corresponding amide was synthesized from the cortienic acid and ethyl ester of b-alanine by dicyclohexylcarbodiimide - hydroxybenzotriazole coupling procedure. Lipophilicity of the amide was evaluated by using reversed-phase thin-layer chromatography systems, consisting of ethanol and water in various ratios, and was higher in comparison to fluocinolone acetonide and cortienic acid.http://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2016/1450-96361638107D.pdfcortienic acidamidelipophilicityRP-TLC |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dobričić Vladimir Vladimirov Sote Čudina Olivera |
spellingShingle |
Dobričić Vladimir Vladimirov Sote Čudina Olivera Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative Kragujevac Journal of Science cortienic acid amide lipophilicity RP-TLC |
author_facet |
Dobričić Vladimir Vladimirov Sote Čudina Olivera |
author_sort |
Dobričić Vladimir |
title |
Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative |
title_short |
Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative |
title_full |
Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative |
title_fullStr |
Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative |
title_full_unstemmed |
Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative |
title_sort |
synthesis and rp-tlc lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative |
publisher |
University of Kragujevac, Faculty of Science |
series |
Kragujevac Journal of Science |
issn |
1450-9636 2466-5509 |
publishDate |
2016-01-01 |
description |
Cortienic acid was obtained by periodic acid oxidation of fluocinolone acetonide, whereas corresponding amide was synthesized from the cortienic acid and ethyl ester of b-alanine by dicyclohexylcarbodiimide - hydroxybenzotriazole coupling procedure. Lipophilicity of the amide was evaluated by using reversed-phase thin-layer chromatography systems, consisting of ethanol and water in various ratios, and was higher in comparison to fluocinolone acetonide and cortienic acid. |
topic |
cortienic acid amide lipophilicity RP-TLC |
url |
http://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2016/1450-96361638107D.pdf |
work_keys_str_mv |
AT dobricicvladimir synthesisandrptlclipophilicityevaluationofanovelfluocinolonacetonidesoftdrugderivative AT vladimirovsote synthesisandrptlclipophilicityevaluationofanovelfluocinolonacetonidesoftdrugderivative AT cudinaolivera synthesisandrptlclipophilicityevaluationofanovelfluocinolonacetonidesoftdrugderivative |
_version_ |
1725500658428149760 |