Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative

Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative

Cortienic acid was obtained by periodic acid oxidation of fluocinolone acetonide, whereas corresponding amide was synthesized from the cortienic acid and ethyl ester of b-alanine by dicyclohexylcarbodiimide - hydroxybenzotriazole coupling procedure. Lipophilicity of the amide was evaluated by using...

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Bibliographic Details
Main Authors:	Dobričić Vladimir, Vladimirov Sote, Čudina Olivera
Format:	Article
Language:	English
Published:	University of Kragujevac, Faculty of Science 2016-01-01
Series:	Kragujevac Journal of Science
Subjects:	cortienic acid amide lipophilicity RP-TLC
Online Access:	http://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2016/1450-96361638107D.pdf

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