Inverse Regulation of Lipocalin-2/24p3 Receptor/SLC22A17 and Lipocalin-2 Expression by Tonicity, NFAT5/TonEBP and Arginine Vasopressin in Mouse Cortical Collecting Duct Cells mCCD(cl.1): Implications for Osmotolerance

Inverse Regulation of Lipocalin-2/24p3 Receptor/SLC22A17 and Lipocalin-2 Expression by Tonicity, NFAT5/TonEBP and Arginine Vasopressin in Mouse Cortical Collecting Duct Cells mCCD(cl.1): Implications for Osmotolerance

The rodent collecting duct (CD) expresses a 24p3/NGAL/lipocalin-2 (LCN2) receptor (SLC22A17) apically, possibly to mediate high-affinity reabsorption of filtered proteins by endocytosis, although its functions remain uncertain. Recently, we showed that hyperosmolarity/-tonicity upregulates SLC22A17...

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Bibliographic Details
Main Authors: Stephanie Probst, Bettina Scharner, Ruairi McErlean, Wing-Kee Lee, Frank Thévenod
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
kidney
hypertonicity
osmotic stress
lipocalin-2
lipocalin-2 receptor
lipopolysaccharide
tonebp
creb
Online Access:https://www.mdpi.com/1422-0067/20/21/5398

Internet

https://www.mdpi.com/1422-0067/20/21/5398

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