Analysis of tumor mutational burden: correlation of five large gene panels with whole exome sequencing

Analysis of tumor mutational burden: correlation of five large gene panels with whole exome sequencing

Abstract Outcome of immune checkpoint inhibition in cancer can be predicted by measuring PDL1 expression of tumor cells. Search for additional biomarkers led to tumor mutational burden (TMB) as surrogate marker for neoantigens presented. While TMB was previously determined via whole exome sequencing...

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Bibliographic Details
Main Authors:	Carina Heydt, Jan Rehker, Roberto Pappesch, Theresa Buhl, Markus Ball, Udo Siebolts, Anja Haak, Philipp Lohneis, Reinhard Büttner, Axel M. Hillmer, Sabine Merkelbach-Bruse
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-07-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-020-68394-4

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