Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

Cryptosporidium infection can cause severe diarrhea with limited treatment options available. Here, Lunde et al. perform a drug repositioning screen with a library of benzoxaboroles and identify AN7973 as potent inhibitor of intracellular parasite development with good efficacy in murine and neonata...

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Bibliographic Details
Main Authors: Christopher S. Lunde, Erin E. Stebbins, Rajiv S. Jumani, Md Mahmudul Hasan, Peter Miller, John Barlow, Yvonne R. Freund, Pamela Berry, Rianna Stefanakis, Jiri Gut, Philip J. Rosenthal, Melissa S. Love, Case W. McNamara, Eric Easom, Jacob J. Plattner, Robert T. Jacobs, Christopher D. Huston
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10687-y

Internet

https://doi.org/10.1038/s41467-019-10687-y

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