Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease
Guillot-Sestier et al investigated sex-related differences in microglia in postmortem brain tissue from Alzheimer’s Disease (AD) patients as well as in the APP/PS1 AD mouse model. They demonstrated that there was differential expression of genes associated with microglial activation and metabolism b...
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Nature Publishing Group
2021-06-01
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Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-021-02259-y |
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doaj-a001442647c94de9a36e380d0601a7a12021-06-13T11:33:32ZengNature Publishing GroupCommunications Biology2399-36422021-06-014111310.1038/s42003-021-02259-yMicroglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s diseaseMarie-Victoire Guillot-Sestier0Ana Rubio Araiz1Virginia Mela2Aline Sayd Gaban3Eoin O’Neill4Lisha Joshi5Edward T. Chouchani6Evanna L. Mills7Marina A. Lynch8Trinity College Institute for Neuroscience, Trinity CollegeTrinity College Institute for Neuroscience, Trinity CollegeTrinity College Institute for Neuroscience, Trinity CollegeTrinity College Institute for Neuroscience, Trinity CollegeTrinity College Institute for Neuroscience, Trinity CollegeGottfried Schatz Research Centre, Medical University of GrazDepartment of Cancer Biology, Dana–Farber Cancer InstituteDepartment of Cancer Biology, Dana–Farber Cancer InstituteTrinity College Institute for Neuroscience, Trinity CollegeGuillot-Sestier et al investigated sex-related differences in microglia in postmortem brain tissue from Alzheimer’s Disease (AD) patients as well as in the APP/PS1 AD mouse model. They demonstrated that there was differential expression of genes associated with microglial activation and metabolism between male and female AD mice as well as differences in morphology that were also apparent in the patient post-mortem tissue, which therefore contributes to our understanding of sexual dimorphism in AD.https://doi.org/10.1038/s42003-021-02259-y |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marie-Victoire Guillot-Sestier Ana Rubio Araiz Virginia Mela Aline Sayd Gaban Eoin O’Neill Lisha Joshi Edward T. Chouchani Evanna L. Mills Marina A. Lynch |
spellingShingle |
Marie-Victoire Guillot-Sestier Ana Rubio Araiz Virginia Mela Aline Sayd Gaban Eoin O’Neill Lisha Joshi Edward T. Chouchani Evanna L. Mills Marina A. Lynch Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease Communications Biology |
author_facet |
Marie-Victoire Guillot-Sestier Ana Rubio Araiz Virginia Mela Aline Sayd Gaban Eoin O’Neill Lisha Joshi Edward T. Chouchani Evanna L. Mills Marina A. Lynch |
author_sort |
Marie-Victoire Guillot-Sestier |
title |
Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease |
title_short |
Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease |
title_full |
Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease |
title_fullStr |
Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease |
title_full_unstemmed |
Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease |
title_sort |
microglial metabolism is a pivotal factor in sexual dimorphism in alzheimer’s disease |
publisher |
Nature Publishing Group |
series |
Communications Biology |
issn |
2399-3642 |
publishDate |
2021-06-01 |
description |
Guillot-Sestier et al investigated sex-related differences in microglia in postmortem brain tissue from Alzheimer’s Disease (AD) patients as well as in the APP/PS1 AD mouse model. They demonstrated that there was differential expression of genes associated with microglial activation and metabolism between male and female AD mice as well as differences in morphology that were also apparent in the patient post-mortem tissue, which therefore contributes to our understanding of sexual dimorphism in AD. |
url |
https://doi.org/10.1038/s42003-021-02259-y |
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