Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease

Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease

Guillot-Sestier et al investigated sex-related differences in microglia in postmortem brain tissue from Alzheimer’s Disease (AD) patients as well as in the APP/PS1 AD mouse model. They demonstrated that there was differential expression of genes associated with microglial activation and metabolism b...

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Main Authors: Marie-Victoire Guillot-Sestier, Ana Rubio Araiz, Virginia Mela, Aline Sayd Gaban, Eoin O’Neill, Lisha Joshi, Edward T. Chouchani, Evanna L. Mills, Marina A. Lynch
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02259-y
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spelling doaj-a001442647c94de9a36e380d0601a7a12021-06-13T11:33:32ZengNature Publishing GroupCommunications Biology2399-36422021-06-014111310.1038/s42003-021-02259-yMicroglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s diseaseMarie-Victoire Guillot-Sestier0Ana Rubio Araiz1Virginia Mela2Aline Sayd Gaban3Eoin O’Neill4Lisha Joshi5Edward T. Chouchani6Evanna L. Mills7Marina A. Lynch8Trinity College Institute for Neuroscience, Trinity CollegeTrinity College Institute for Neuroscience, Trinity CollegeTrinity College Institute for Neuroscience, Trinity CollegeTrinity College Institute for Neuroscience, Trinity CollegeTrinity College Institute for Neuroscience, Trinity CollegeGottfried Schatz Research Centre, Medical University of GrazDepartment of Cancer Biology, Dana–Farber Cancer InstituteDepartment of Cancer Biology, Dana–Farber Cancer InstituteTrinity College Institute for Neuroscience, Trinity CollegeGuillot-Sestier et al investigated sex-related differences in microglia in postmortem brain tissue from Alzheimer’s Disease (AD) patients as well as in the APP/PS1 AD mouse model. They demonstrated that there was differential expression of genes associated with microglial activation and metabolism between male and female AD mice as well as differences in morphology that were also apparent in the patient post-mortem tissue, which therefore contributes to our understanding of sexual dimorphism in AD.https://doi.org/10.1038/s42003-021-02259-y
collection DOAJ
language English
format Article
sources DOAJ
author Marie-Victoire Guillot-Sestier
Ana Rubio Araiz
Virginia Mela
Aline Sayd Gaban
Eoin O’Neill
Lisha Joshi
Edward T. Chouchani
Evanna L. Mills
Marina A. Lynch
spellingShingle Marie-Victoire Guillot-Sestier
Ana Rubio Araiz
Virginia Mela
Aline Sayd Gaban
Eoin O’Neill
Lisha Joshi
Edward T. Chouchani
Evanna L. Mills
Marina A. Lynch
Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease
Communications Biology
author_facet Marie-Victoire Guillot-Sestier
Ana Rubio Araiz
Virginia Mela
Aline Sayd Gaban
Eoin O’Neill
Lisha Joshi
Edward T. Chouchani
Evanna L. Mills
Marina A. Lynch
author_sort Marie-Victoire Guillot-Sestier
title Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease
title_short Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease
title_full Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease
title_fullStr Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease
title_full_unstemmed Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease
title_sort microglial metabolism is a pivotal factor in sexual dimorphism in alzheimer’s disease
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-06-01
description Guillot-Sestier et al investigated sex-related differences in microglia in postmortem brain tissue from Alzheimer’s Disease (AD) patients as well as in the APP/PS1 AD mouse model. They demonstrated that there was differential expression of genes associated with microglial activation and metabolism between male and female AD mice as well as differences in morphology that were also apparent in the patient post-mortem tissue, which therefore contributes to our understanding of sexual dimorphism in AD.
url https://doi.org/10.1038/s42003-021-02259-y
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