Probenecid Pre-treatment Downregulates the Kidney Cl-/HCO3- Exchanger (Pendrin) and Potentiates Hydrochlorothiazide-Induced Diuresis

Probenecid Pre-treatment Downregulates the Kidney Cl-/HCO3- Exchanger (Pendrin) and Potentiates Hydrochlorothiazide-Induced Diuresis

Background: Probenecid is a uricosuric agent that in addition to exerting a positive ionotropic effect in the heart, blocks the ATP transporter Pannexin 1 and inhibits the Cl-/HCO3- exchanger, pendrin. In the kidney, pendrin blunts the loss of salt wasting secondary to the inhibition of the thiazide...

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Bibliographic Details
Main Authors: Sharon Barone, Jie Xu, Kamyar Zahedi, Marybeth Brooks, Manoocher Soleimani
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Physiology
Subjects:
Na+-Cl- co-transporter
pendrin
collecting duct
distal convoluted tubule
salt
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00849/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.00849/full

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