SeqClone: sequential Monte Carlo based inference of tumor subclones

SeqClone: sequential Monte Carlo based inference of tumor subclones

Abstract Background Tumor samples are heterogeneous. They consist of varying cell populations or subclones and each subclone is characterized with a distinct single nucleotide variant (SNV) profile. This explains the source of genetic heterogeneity observed in tumor sequencing data. To make precise...

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Bibliographic Details
Main Authors: Oyetunji E. Ogundijo, Xiaodong Wang
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Bioinformatics
Subjects:
Tumor heterogeneity
Bayesian model
Sequential Monte Carlo
Indian buffet process
Online Access:http://link.springer.com/article/10.1186/s12859-018-2562-y

Internet

http://link.springer.com/article/10.1186/s12859-018-2562-y

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