Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice.

Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice.

BACKGROUND: Cachexia is among the most debilitating and life-threatening aspects of cancer. It represents a metabolic syndrome affecting essential functional circuits involved in the regulation of homeostasis, and includes anorexia, fat and muscle tissue wasting. The anorexigenic peptide alpha-MSH i...

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Bibliographic Details
Main Authors: Philipp Weyermann, Robert Dallmann, Josef Magyar, Corinne Anklin, Martina Hufschmid, Judith Dubach-Powell, Isabelle Courdier-Fruh, Marco Henneböhle, Sonja Nordhoff, Cesare Mondadori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2654097?pdf=render

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http://europepmc.org/articles/PMC2654097?pdf=render

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