Frequent <i>FOXA1</i>-Activating Mutations in Extramammary Paget’s Disease

Frequent <i>FOXA1</i>-Activating Mutations in Extramammary Paget’s Disease

Extramammary Paget’s disease (EMPD) is a neoplastic skin disease of indeterminate origin with an unknown genetic cause. We performed a comprehensive genetic analysis or targeted gene sequencing in 48 patients with EMPD. We identified <i>FOXA1</i> mutations, a <i>GAS6–FOXA1</i>...

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Bibliographic Details
Main Authors: Takuya Takeichi, Yusuke Okuno, Takaaki Matsumoto, Nobuyuki Tsunoda, Kyogo Suzuki, Kana Tanahashi, Michihiro Kono, Toyone Kikumori, Yoshinao Muro, Masashi Akiyama
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
extramammary Paget’s disease
forkhead box A1
fusion gene
mammary Paget’s disease
somatic mutations
whole-genome sequencing
Online Access:https://www.mdpi.com/2072-6694/12/4/820

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https://www.mdpi.com/2072-6694/12/4/820

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