The Phosphatase SHP-2 Activates HIF-1α in Wounds In Vivo by Inhibition of 26S Proteasome Activity

The Phosphatase SHP-2 Activates HIF-1α in Wounds In Vivo by Inhibition of 26S Proteasome Activity

Vascular remodeling and angiogenesis are required to improve the perfusion of ischemic tissues. The hypoxic environment, induced by ischemia, is a potent stimulus for hypoxia inducible factor 1α (HIF-1α) upregulation and activation, which induce pro-angiogenic gene expression. We p...

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Bibliographic Details
Main Authors: Yvonn Heun, Katharina Grundler Groterhorst, Kristin Pogoda, Bjoern F Kraemer, Alexander Pfeifer, Ulrich Pohl, Hanna Mannell
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
SHP-2
tyrosine phosphatase
HIF-1
26S proteasome
hypoxia
vascular remodeling
angiogenesis
Online Access:https://www.mdpi.com/1422-0067/20/18/4404

Internet

https://www.mdpi.com/1422-0067/20/18/4404

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