Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways

Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways

Large-conductance and Ca2+-activated K+ (BK) channels are expressed in human hepatic stellate cells (HSCs), where they have roles in normal hepatic microcirculation, as well as in portal hypertension in liver cirrhosis through the regulation of contractility in activated HSCs. Nevertheless, whether...

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Bibliographic Details
Main Authors: Linli Yang, Bo Han, Man Zhang, Ya-Hui Wang, Kun Tao, Michael X. Zhu, Kunyan He, Zhi-Gang Zhang, Shangwei Hou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
liver fibrosis
hepatic stellate cells
BK
KCNMA1
TGFβ1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00165/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00165/full

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