Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models.

Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models.

BACKGROUND: Compound targeting histone deacetylase (HDAC) represents a new era in molecular cancer therapeutics. However, effective HDAC inhibitors for the treatment of solid tumors remain to be developed. METHODOLOGY/PRINCIPAL FINDINGS: Here, we propose a novel HDAC inhibitor, N-Hydroxy-4-(4-phenyl...

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Main Authors: Jiunn-Min Shieh, Tzu-Tang Wei, Yen-An Tang, Sin-Ming Huang, Wei-Ling Wen, Mei-Yu Chen, Hung-Chi Cheng, Santosh B Salunke, Ching-Shih Chen, Pinpin Lin, Chien-Tien Chen, Yi-Ching Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3261198?pdf=render

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http://europepmc.org/articles/PMC3261198?pdf=render

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