Positively charged cyclodextrins as effective molecular transporters of active phosphorylated forms of gemcitabine into cancer cells

Positively charged cyclodextrins as effective molecular transporters of active phosphorylated forms of gemcitabine into cancer cells

Abstract Positively charged cyclodextrins (PCCDs) are molecular carriers of particular interest for their ability to readily enter into cancer cells. Of main interest, guanidino- and aminoalkyl- PCCDs can be conveniently synthesized and form stable and strong inclusion complexes with various active...

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Bibliographic Details
Main Authors: Violeta Rodriguez-Ruiz, Andrey Maksimenko, Giuseppina Salzano, Maria Lampropoulou, Yannis G. Lazarou, Valentina Agostoni, Patrick Couvreur, Ruxandra Gref, Konstantina Yannakopoulou
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08727-y

Internet

https://doi.org/10.1038/s41598-017-08727-y

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