Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice

Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice

Heterozygous mutations in the PINK1 gene are considered a susceptibility factor to develop early-onset Parkinson's disease (PD), as supported by dopamine hypometabolism in asymptomatic mutation carriers and subtle alterations of dopamine-dependent striatal synaptic plasticity in heterozygous PI...

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Bibliographic Details
Main Authors: G. Martella, G. Madeo, M. Maltese, V. Vanni, F. Puglisi, E. Ferraro, T. Schirinzi, E.M. Valente, L. Bonanni, J. Shen, G. Mandolesi, N.B. Mercuri, P. Bonsi, A. Pisani
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
PINK1 heterozygous mutations
Electrophysiology
Synaptic plasticity
Striatum
Rotenone
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115301200

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http://www.sciencedirect.com/science/article/pii/S0969996115301200

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