Development of a HLA-B*58:01 Allele Screening System for Allopurinol-Induced Severe Cutaneous Adverse Reactions Detection

Development of a HLA-B*58:01 Allele Screening System for Allopurinol-Induced Severe Cutaneous Adverse Reactions Detection

The HLA-B*58:01 allele has been identified as a genetic marker in the fatal allopurinol-induced severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). However, the screening of the HLA-B*58:01 allele prior to allopurinol prescription h...

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Bibliographic Details
Main Authors: Kok Beng Gan, Kim Soon Chong, Anusha Devi Nawoor, Sue-Mian Then, Nor Azian Abdul Murad, A. Rahman A. Jamal
Format: Article
Language:English
Published: IEEE 2020-01-01
Series:IEEE Access
Subjects:
Polymerase chain reaction
high resolution melting
HLA-B*58:01 allele
severe cutaneous adverse reactions (SCARs)
difference melt curve
Online Access:https://ieeexplore.ieee.org/document/9293282/

Internet

https://ieeexplore.ieee.org/document/9293282/

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