Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease

Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease

Abstract Background Identifying and understanding the functional role of genetic risk factors for Alzheimer disease (AD) has been complicated by the variability of genetic influences across brain regions and confounding with age-related neurodegeneration. Methods A gene co-expression network was con...

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Bibliographic Details
Main Authors: Daniel Lancour, Josée Dupuis, Richard Mayeux, Jonathan L. Haines, Margaret A. Pericak-Vance, Gerard C. Schellenberg, Mark Crovella, Lindsay A. Farrer, Simon Kasif
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer disease
Gene network analysis
Brain regions
Genome-wide association study
EPS8
HSPA2
Online Access:http://link.springer.com/article/10.1186/s13195-020-00674-7

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http://link.springer.com/article/10.1186/s13195-020-00674-7

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