Dimensionality reduction by UMAP to visualize physical and genetic interactions

Dimensionality reduction is often used to visualize expression profiling data in order to find relationships among cells. Here, the authors use Uniform Manifold Approximation and Projection (UMAP) on published expression data of gene deletions of S. cerevisiae to find novel protein interactions.

Bibliographic Details
Main Authors: Michael W. Dorrity, Lauren M. Saunders, Christine Queitsch, Stanley Fields, Cole Trapnell
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15351-4