Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

The alarmone (p)ppGpp regulates diverse targets, yet its target specificity and evolution remain poorly understood. Here, we elucidate the mechanism by which basal (p)ppGpp inhibits the purine salvage enzyme HPRT by sharing a conserved motif with its substrate PRPP. Intriguingly, HPRT regulation by...

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Bibliographic Details
Main Authors: Brent W Anderson, Kuanqing Liu, Christine Wolak, Katarzyna Dubiel, Fukang She, Kenneth A Satyshur, James L Keck, Jue D Wang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
(p)ppGpp
allosteric regulation
enzyme oligomerization
signaling ligand
protein evolution
bacterial homeostasis
Online Access:https://elifesciences.org/articles/47534

Internet

https://elifesciences.org/articles/47534

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