Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1

Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1

Argininosuccinate synthase 1 (ASS1) is the rate-limiting enzyme for arginine biosynthesis. ASS1 expression is lost in a range of tumor types, including 50% of malignant pleural mesotheliomas. Starving ASS1-deficient cells of arginine with arginine blockers such as ADI-PEG20 can induce selective leth...

Full description

Bibliographic Details
Main Authors: Matthew Locke, Essam Ghazaly, Marta O. Freitas, Mikaella Mitsinga, Laura Lattanzio, Cristiana Lo Nigro, Ai Nagano, Jun Wang, Claude Chelala, Peter Szlosarek, Sarah A. Martin
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471630866X

Internet

http://www.sciencedirect.com/science/article/pii/S221112471630866X

Similar Items