A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor

A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor

Abstract Chronic exposure to ambient polycyclic aromatic hydrocarbons (PAHs) is associated with asthma, but its regulatory mechanisms remain incompletely defined. We report herein that elevated levels of urinary 1-hydroxypyrene, a biomarker of PAH exposure, were found in asthmatic subjects (n = 39)...

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Bibliographic Details
Main Authors: Tzu-Hsuan Wong, Chon-Lin Lee, Hsiang-Han Su, Chin-Lai Lee, Chao-Chien Wu, Chin-Chou Wang, Chau-Chyun Sheu, Ruay-Sheng Lai, Sum-Yee Leung, Chi-Cheng Lin, Yu-Feng Wei, Chien-Jen Wang, Yu-Chun Lin, Hua-Ling Chen, Ming-Shyan Huang, Jeng-Hsien Yen, Shau-Ku Huang, Jau-Ling Suen
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-23542-9

Internet

https://doi.org/10.1038/s41598-018-23542-9

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