Combinatory antibiotic therapy increases rate of bacterial kill but not final outcome in a novel mouse model of Staphylococcus aureus spinal implant infection.

Combinatory antibiotic therapy increases rate of bacterial kill but not final outcome in a novel mouse model of Staphylococcus aureus spinal implant infection.

BACKGROUND:Management of spine implant infections (SII) are challenging. Explantation of infected spinal hardware can destabilize the spine, but retention can lead to cord compromise and biofilm formation, complicating management. While vancomycin monotherapy is commonly used, in vitro studies have...

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Bibliographic Details
Main Authors: Yan Hu, Vishal Hegde, Daniel Johansen, Amanda H Loftin, Erik Dworsky, Stephen D Zoller, Howard Y Park, Christopher D Hamad, George E Nelson, Kevin P Francis, Anthony Scaduto, Nicholas M Bernthal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5330510?pdf=render

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http://europepmc.org/articles/PMC5330510?pdf=render

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