In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells

In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells

Abundant IFN-γ secretion, potent cytotoxicity, and major histocompatibility complex-independent targeting of a large spectrum of tumors make γδ T cells attractive candidates for cancer immunotherapy. Upon tumor recognition through the T-cell receptor (TCR), NK-receptors, o...

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Bibliographic Details
Main Authors: Karin Schilbach, Christian Welker, Naomi Krickeberg, Carlotta Kaißer, Sabine Schleicher, Hisayoshi Hashimoto
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
γδ t cells
il-12
il-18
senescence
tcr bypass stimulation
Online Access:https://www.mdpi.com/2072-6694/12/1/130

Internet

https://www.mdpi.com/2072-6694/12/1/130

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