Effect of transcription inhibition and generation of suppressive viral non-coding RNAs

Effect of transcription inhibition and generation of suppressive viral non-coding RNAs

Abstract Background HIV-1 patients receiving combination antiretroviral therapy (cART) survive infection but require life-long adherence at high expense. In chronic cART-treated patients with undetectable viral titers, cell-associated viral RNA is still detectable, pointing to low-level viral transc...

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Bibliographic Details
Main Authors: Daniel O. Pinto, Tristan A. Scott, Catherine DeMarino, Michelle L. Pleet, Thy T. Vo, Mohammed Saifuddin, Dmytro Kovalskyy, James Erickson, Maria Cowen, Robert A. Barclay, Chen Zeng, Marc S. Weinberg, Fatah Kashanchi
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Retrovirology
Subjects:
HIV-1
Transcription
Latency
Gene silencing
cART
CRISPR
Online Access:http://link.springer.com/article/10.1186/s12977-019-0475-0

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http://link.springer.com/article/10.1186/s12977-019-0475-0

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