Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling

Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling

Abstract Background In the quest for new anti-cancer drugs, the drug discovery process has shifted to screening of active ingredients in traditional eastern medicine. Matrine is an active alkaloid isolated from plants of the Sophora genus used in traditional Chinese herbal medicine that exhibits a w...

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Bibliographic Details
Main Authors: Yuming Zou, Melika Sarem, Shengnan Xiang, Honggang Hu, Weidong Xu, V. Prasad Shastri
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Cancer
Subjects:
Matrine
Matrine derivate
Autophagy
Apoptosis
Anti-cancer
Reactive oxygen species
Online Access:http://link.springer.com/article/10.1186/s12885-019-6199-7

Internet

http://link.springer.com/article/10.1186/s12885-019-6199-7

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