A Systematic Assessment of Accuracy in Detecting Somatic Mosaic Variants by Deep Amplicon Sequencing: Application to NF2 Gene.

A Systematic Assessment of Accuracy in Detecting Somatic Mosaic Variants by Deep Amplicon Sequencing: Application to NF2 Gene.

The accurate detection of low-allelic variants is still challenging, particularly for the identification of somatic mosaicism, where matched control sample is not available. High throughput sequencing, by the simultaneous and independent analysis of thousands of different DNA fragments, might overco...

Full description

Bibliographic Details
Main Authors: Elisa Contini, Irene Paganini, Roberta Sestini, Luisa Candita, Gabriele Lorenzo Capone, Lorenzo Barbetti, Serena Falconi, Sabrina Frusconi, Irene Giotti, Costanza Giuliani, Francesca Torricelli, Matteo Benelli, Laura Papi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4466335?pdf=render

Internet

http://europepmc.org/articles/PMC4466335?pdf=render

Similar Items