Exposure of Breast and Lung Cancer Cells to a Novel Estrone Analog Prior to Radiation Enhances Bcl-2-Mediated Cell Death

Exposure of Breast and Lung Cancer Cells to a Novel Estrone Analog Prior to Radiation Enhances Bcl-2-Mediated Cell Death

Following exposure of cells to gamma-radiation, a cascade of intracellular consequences may be observed in a semitemporal manner. This includes deoxyribonucleic acid (DNA) damage and reactive oxygen species (ROS) accumulation initially, with consequent signaling for DNA repair and facilitative regul...

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Bibliographic Details
Main Authors: Elsie M. Nolte, Anna M. Joubert, Roy Lakier, Ado van Rensburg, Anne E. Mercier
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
cancer
radiation therapy
2-methoxyestradiol
ESE-15-ol
radiosensitization
apoptosis
Bcl-2
reactive oxygen species
clonogenic studies
Online Access:http://www.mdpi.com/1422-0067/19/10/2887

Internet

http://www.mdpi.com/1422-0067/19/10/2887

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